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Location: Home>Papers of Analysis and Testing Technology and Instruments
Metabonomic Analysis of Rat Urine Using Nuclear Magnetic Resonance Spectroscopy
2010-11-01 ArticleSource:
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BATUR·Mamtimin1, 2, MAMAT·Amat3, AYSHAMGUL·Hasim4, IBRAYIM·Ismayil1

(1.College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China; 2. College of Pharmacy, Zhongnan University, Changsha 410007, China; 3. Institute For Drug Control, Kumul 839000, China; 4. Basic College, Xinjiang Medical University, Urumqi 830054, China)

Abstract: The metabonomic groups of male and female rat urine have been investigated by nuclear magnetic resonance (NMR) spectroscopy. Two pattern recognition techniques including the principal component analysis (PCA) and the orthogonal to partial least squares discriminant analysis (OPLS-DA) were used to find the difference of metabolic groups between male and female rats, respectively. The results of PCA and OPLS-DA analyses indicated that the amounts of valine, alanine, acetate, thiamine, ornithine, aminohippurate, phenylethylamine and cytosine in the urine samples of female rats were obviously higher than in those of male rats, based on the sufficient statistical variation (p<0.05). On the other hand, the amounts of methylamine, dimethylamine, trimethylamine, creatinine, allantoin, fumarate, formate in the urine samples of male rats were higher than those of female rats (p<0.05). The results showed that the gender of rat has certain effects on the metabolites of rat urine.

Key words: metabonomics; nuclear magnetic resonance; gender difference

E-mail: mtbatu@yahoo.com.cn

Analysis and Testing Technology and Instruments, Vol. 16, No. 3, 2010, 157-161.

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