CHEN Yi-ting*, SU Bi-Ling, HUANG Lu, LIN Qi
(Chemistry and Chemical Engineering Department of Minjiang University, Fuzhou Fujian 350108)
Abstract: Both the dissociation constants of famciclovir obtained were 3.8 using ultraviolet spectrophotometry with the wavelengths at 225 nm and 305 nm. Bovine serum albumin was added to a Na2HPO4-KH2PO4 buffer solution (pH 7.0) with famciclovir. The binding constant was measurd by the double-reciprocal analysis. The results showed that the bovine serum albumin and famciclovir formed a 1:4 complex, and the binding constant obtained was 4.51×106L/mol. This method is simple and reliable.
Key words: Famciclovir; ultraviolet spectrophotometry; dissociation constant; bovine serum albumin; binding constant
E-mail: fjcyt@foxmail.com
Analysis and Testing Technology and Instruments, Vol. 17, No. 1, 2011, 1-5.
