XIONG Dong-lu^1,2,WANG Shou-feng¹, SUN Wei^1*

(1. State Key Laboratory for Oxo Synthesis and Seletive Oxidation , Lanzhou Institute of Chemical Physics , Chinese Academy of Sciences, Lanzhou 73000, China 2. Graduate University of Chinese Academy of Sciences, Beijing 10009, China)

Abstract: The Biaryl-bridged Salen Ti complexes are catalytically active at substrate-to-catalyst ratios as high as 1000:1 in the reaction of asymmetric addition of trimethylsilyl cyanide to aldehydes, and the optimal catalyst 4 derived from (R,R)-1,2-diaminocyclohexane and 3,5-di-tert-butyl-2-hydroxybenzaldehyde produces trimethylsilyl ethers of cyanohydrins with up to 87% enantiomeric excess at ambient temperature.

Key words: Salen Ti; biaryl-bridged; Trimethylsilyl cyanide; Aldehydes

E-mail: wsun@licp.cas.cn

Journal of Molecular Catalysis, Vol. 25, Issue 1, 2011, 1~5