NAN Pengjuan1 CHEN Jin1 SUN Xiaoli2
( 1 School Of Chemistry Materials Science,Shaanxi Normal University, 2 The Fourth Military Medical University Department of Chemistry, Xi’an, 710062)
Abstract: A reusable free cinchona alkaloid derivative ligand was applied to asymmetric aminohydroxylation (AA) of 5 five methyl cinnamates with 91%-96% e.e .and 52%-72% yields. In the AA reaction of methyl cinnamates, this ligand can be easily recovered and reused without any significant loss in its catalytic efficiency by two defferent methods. this ligand was applied to the catalytic asymmetric aminohydroxylation to produce enantioselective α-aminoacid esters.
Key words: reusable free ligand; AA reaction; chiral β-amino alcohol; chiral α-aminoacid ester
E-mail: npj.fmmu@sina.com
Journal of Molecular Catalysis, Vol. 25, Issue 2, 2011, 109~113
