Xing Ai-ping^1,2, Wang Lai-lai^{1 *}, Kwok Waihim³

(1 State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2 Gradutae University of Chinese Academy of Sciences, Beijing 100039, China 3 Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, P R China)

Abstract: The in situ prepared chiral catalyst of Pd / unchelating bidentate phosphine ligand L1 (DPPFF), bipyridine bidentate phosphine ligand L2 (P-PHOS), and bidentate phosphine ligand L3 ((S, Rp)-BPPF), and Rh / phosphite ligands L4 –L6, have been applieded in amidocarbonylation of cyclohexanecarboxaldehyde or phenylacetaldehyde.Pd / bipyridine bidentate phosphine ligand L2 gave the enantioselectivity 25% (S) and the yield 11%in amidocarbonylation of phenylacetaldehyde ,When Pd / unchelating bidentate phosphine ligand L1 was employed in asymmetric amidocarbonylation of cyclohexanecarboxaldehyde,the enantioselectivity 4.3% (S) and the yield 15% were received.

Key words: Palladiumbromide; acetylacetonatodicarbonyl rhodium; Cyclohexanecarboxaldehyde; Phenylacetaldehyde: Chiral phosphine and phosphite ligands; Asymmetric amidocarbonylation

E-mail: wll@licp.cas.cn

Journal of Molecular Catalysis, Vol. 25, Issue 3, 2011, 202~207