LV Cheng-wei^{1, 2}, CHENG Qi-gan¹, WANG Shou-feng¹, SUN Wei^1*

 (1 State Key Laboratory for Oxo Synthesis and Seletive Oxidation, Lanzhou Institute of Chemical Physics, Lanzhou 73000, China 2 Chinese Academy of Sciences, Beijing, 100039, China)

Abstract: In order to ameliorate the asymmetric inductivity and catalytic activity of the salen ligands with pyrrolidine diamine collar, Lewis acid and Lewis base group have been introduced at different positions of the salen unit. These new bifunctional N-oxide salen-Ti catalysts were successfully synthesized and applied to the catalytic asymmetric cyanosilylation of ketones in mild conditions. The products were obtained generally with moderate enantiomeric excesses and excellent yields.

Key words:Chiral N-oxide salen-Ti; Bifunctional catalyst; Ketones; Asymmetric cyanosilylation

E-mail: wsun@licp.cas.cn

Journal of Molecular Catalysis, Vol. 25, Issue 4, 2011, 295~300