WANG Mengliang, CUI Bingjian
(Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China)
Abstract: Acetophenone was selected as the model substrate, and monophasic and biphasic ionic liquid/buffer reaction systems were built respectively through three typical ionic liquids. The systematic study to the reaction characteristics of immobilized photosynthetic bacteria has been inuestigated. Based on optimization of reaction conditions and systems, we found that the use of ionic liquids instead of conventional solvents give better results than aqueous phase and organic phase systems.Furthermore, ionic liquids and immobilized cells can be recycled. The results indicate that immobilized photosynthetic bacteria can catalyze acetophenone to product corresponding (S)\|phenylethanol mainly under the optimised conditions, such as in hydrophilic ionic liquid [EMIM] [EtSO4] with 15% volume fraction as monophasic ionic liquid/buffer reaction system. The yield and the enantiomeric excess values (ee) of (S)\|phenylethanol were 82.7% and up to 99%, respectively. Ionic liquids not only enhance the catalytic reaction rate, but also increase the stability of biocatalysts. The reaction medium can be recycled and improve environmental friendiness of the systems.
Key words: ionic liquids; immobilized photosynthetic bacteria; asymmetric reduction; acetophenone
E-mail: mlwang@sxu.edu.cn
Journal of Molecular Catalysis, Vol. 25, Issue 5, 2011, 427-434
