ZENG Peiwei1, DENG Jun2, CAO Zhong1, ZHENG Zhuo2, HU Xiangping2*
(1.School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha 410004, China; 2. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China)
Abstract: A series of BoPhoz-type phosphine-aminophosphine ligands were employed in the Rh-catalyzed asymmetric hydrogenation of beta-(acylamino)acrylates. The results indicated that the structure of BoPhoz-type ligands has a significant influence on this hydrogenation, and ligand 3c bearing bis[(3,5-difluoro)phenyl]phosphinoamino moiety and bis[(3,5-dimethyl)phenyl]- phosphino moiety showed the best enantioselectivity. Under the optimal conditions, a variety of beta-(acylamino)acrylates were hydrogenated in enantioselectivities of up to 81% ee.
Key words: phosphine-aminophosphine ligands; rhodium; hydrogenation; asymmetric catalysis; beta-(acylamino)acrylate
E-mail: xiangping@dicp.ac.cn
Journal of Molecular Catalysis, Vol. 25, Issue 6, 2011, 485-488
