Abstract
We prepared two-dimensional (2D) bimetallic metal-organic frameworks (Ni-ZIF-8) nanosheets by a simple solvent-free method at room temperature. The morphology and composition of Ni-ZIF-8 can be controlled through adding different amounts of Ni. And then, the 2D magnetic mesoporous nanosheets (Ni/ZnO@C) were synthesized by directly pyrolyzing Ni-ZIF-8 under argon atmosphere and explored as magnetic solid phase extraction (MSPE) adsorbents for the determination of nitroimidazole antibiotics (NIABs). Magnetic Ni nanoparticles embedded in carbon nanosheets uniformly resulted in high magnetization saturation of Ni/ZnO@C for easy separation. The Ni/ZnO@C can form hydrogen bond and pi-pi interaction with three NIABs resulting from their rich N-H containing imidazole, pi-electron. Due to the high specific surface area and high mass transfer rate of 2D Ni/ZnO@C, the materials showed satisfactory adsorption capacity and rapid adsorption kinetics for NIABs. A rapid and effective method of Ni/ZnO@C-MSPE combined with high-performance liquid chromatography was proposed for the determination of NIABs. Several main parameters affecting MSPE were investigated. Under the optimal conditions, wide linear was achieved ranging from 0.1 to 500 mu g.L-1 with a low detection limit of 0.025-0.05 mu g.L-1. The established method has been successfully applied to analyze NIABs from environmental water samples with satisfactory recovery from 74.33 to 105.71%. (C)2021 Published by Elsevier B.V.

KeyWords Plus:5-NITROIMIDAZOLES; METABOLITES; SAMPLES; RESIDUES; GRAPHENE; HONEY; WATER

Published in JOURNAL OF CHROMATOGRAPHY A，Volume 1645；10.1016/j.chroma.2021.462074，MAY 24 2021