Abstract
In this work, three new mixed-mode stationary phases were prepared, based on different ratio of N vinyl pyrrolidone (NVP) copolymerized together with undecylenic acid (UA) on silica microspheres surface without silanization, which named Sil@NVPUA series. The combination of NVP and UA rendered the Sil@NVPUA suitable for reversed-phase liquid chromatography (RPLC) and hydrophilic interaction liquid chromatography (HILIC), and shown excellent methyl, planar, isomers and ion selectivity. Five types of model analytes including eight polycyclic aromatic hydrocarbons, six alkylbenzenes, eight nucleosides and nucleobases, seven ginsenosides and five oxazolidinones can be well separated on this stationary phase. The preparation method of NVP and UA modified silica-based stationary phase is simple, and it also provides a new idea for the design of synthetic polymers to develop mixed-mode chromatography. (c) 2021 Elsevier B.V. All rights reserved.

Keywords Plus：TRANSFER RADICAL POLYMERIZATIONCONTROLLABLE PREPARATION

Published in JOURNAL OF CHROMATOGRAPHY A，Volume 1655；10.1016/j.chroma.2021.462534，OCT 11 2021