Abstract
Manganese-catalyzed C-H bond functionalization of aryl amidines for the synthesis of 1-aminoisoquinolines in the presence of vinylene carbonate has been developed. The reaction features a broad substrate scope and proceeds under mild reaction conditions with only the carbonate anion as the byproduct.

Keywords Plus：BOND ACTIVATIONALKYNESACCESSALKENYLATIONISOQUINOLINEIMIDAMIDESARYLATIONFUNCTIONALIZATIONDERIVATIVESKETOXIMES

Published in JOURNAL OF ORGANIC CHEMISTRY，Volume86；10.1021/acs.joc.1c02473，DEC 17 2021