Abstract
The exploration of advanced porous materials in separation science has received great attention for analytical chemistry, and chromatographic separation is also an important process in analytical chemistry. Metal-organic frameworks (MOFs) have emerged as a special class of porous crystalline materials, the unique features like framework flexibility and chirality make MOFs very attractive than other classes of porous materials. With the development of water-stability MOFs and post-modification technology, the increasingly active exploration of MOFs and MOF-based composites has been witnessed for widespread liquid phase applications. This review briefly summarizes the performances and recent application or progress of MOF-based core-shell composites used as stationary phases in the field of highperformance liquid chromatography. It provides a detailed discussion about the application of MOFbased composites for separating analytes under different conditions. Finally, the challenges and prospects about the application of core-shell MOF-based composites in separation science by means of coreshell MOF-based composites are described. (C) 2022 Elsevier B.V. All rights reserved.

Keywords Plus:PERFORMANCE LIQUID-CHROMATOGRAPHYZEOLITIC IMIDAZOLATE FRAMEWORK-8REVERSED-PHASEMODIFIED SILICA2D MOFSEPARATIONRESOLUTIONWATERADSORPTIONEXTRACTION

Published in TRAC-TRENDS IN ANALYTICAL CHEMISTRY,Volume149;10.1016/j.trac.2022.116545,APR 2022