Abstract

Establishing highly sensitive analytical methods to monitor endocrine disrupting chemicals (EDCs) is essential to ensure food safety and human health. Herein, we report a nanoarchitectonics approach to fabricate a MXene and COF heterostructure (Ti3C2TX/TAPT-TFTA) via in situ growth of a beta-ketoenamine-linked COF on the Ti3C2TX MXene. The Ti3C2TX/TAPT-TFTA exhibits remarkable extraction capacity for EDCs. The extraction mechanism was systematically investigated through experiments and density functional theory (DFT) calculations. Thus, an analytical method of EDCs employing Ti3C2TX/TAPT-TFTA as dispersive solid-phase adsorbent was established, coupled with HPLC-PDA. The method achieved detection limits of 0.003-0.006 mu g center dot mL-1 with a linear range of 0.020-1.00 mu g center dot mL-1, while recoveries of 79.4-109.9 % and the relative standard deviations of 0.1-6.1 %. These results validate the proposed method as a reliable and effective approach for the sensitive determination of EDCs in complex food matrices, such as beef, chicken, and pork samples.

Published in JOURNAL OF CHROMATOGRAPHY A，Volume1766；10.1016/j.chroma.2025.466629，JAN 11 2026